@joemurphy43 I go through this site every morning and try to be helpful with what's happening to my husband, as helping others is making my journey a little easier. My husband is on Lequembe, Medicare approved, a few people have asked about the cost, but I'd have to look at the Medicare sheets and his Plan G, I know it's expensive but covered except whatever your gap deductible is. My husband is on the 16th infusion, he has two left before he goes on maintenance. I don't know if I see a "huge difference." I do see that he's more aware of keeping his nap sack (with this things) in one place, the car key and the phone. Before he was losing everything, all the time. I do believe his short term memory loss is a bit better, he remembers people's names when talking, he doesn't trip up the way he did before. But his ability to sequence and work through issues in the house and be a helping partner, isn't there. For us, the infusions, were a no brainer. Anything that might help slow down this horrible disease, is the way we felt we had to go - and he was very positive over doing it. In the program, we're in, in South Florida, the infusion center has a GUIDE program, that monitors, a nurse to answer phone calls, that helps if you need help, and my understanding is an additional $2500.00 if you need some companion home care (so you can get away from doing everything every day). I haven't checked into that yet, but I'm going to. I can only tell you one day I was sitting at the neurologist, and a man who had been on 16 infusions, came in with his wife. He was able to fill out the form for the first time. They saw marked improvement; his wife noticed and so did he, a big difference in his memory. We just have to take the good with the bad, and hope the risk taken results in a slowing down the progression. Hope this helps. Best, Karla