I have had ideopathic peripheral neuropathy almost 30 years. It affects both legs, calves down. I have tried just about everything I hear about but nothing has helped. I also have PKD & PLD but haven't needed treatment for them. I take gabapentin, methadone, & amtriptylene for pain but have a lot of break thru pain. My toes are the worst. I am always looking for ways to help the pain. I use lidocaine patches when needed.