@happyquilter - welcome to Mayo Clinic Connect. I'm sorry to hear about this side effect with starting on the sertraline (Zoloft). It would be completely legitimate to let this doctor know by phone call or portal message now that you've had this experience and that you need a different medication.

Here's some information from Mayo Clinic on this medication, which may be useful:

- Sertraline (oral route) https://www.mayoclinic.org/drugs-supplements/sertraline-oral-route/description/

I do know from my personal experience trying out different antidepressants that it's hard to know if a prescribed medication will work for you till you try, and some will even have challenging side effects at first and then things will calm. It's a tough road trying to find the med that will work the best for you and your body chemistry. However, it was worth it when I found (and got through the first few months of emotional bumps) with the antidepressant that ended up working for me, buproprion (Wellbutrin).

Is your doctor aware of the memory loss you experienced? If so, what did he or she say about that?