I can relate to this set of problems. In the past I could take any antibiotic with the normal reactions--diarrhea, loss of appetite. In 2019 I was diagnosed with MAC and pseudomonas. I was started on the big 3. The pulmonary doctor I had did not know how they should be taken and the many options for dosing. He had me take all of them first thing in the morning on an empty stomach. I lasted six weeks and lost 15 pounds--I'm 5'7" and only weighed 130 at the time. I had nausea, no appetite and diarrhea. He finally told me to stop taking them. He sent me out the door saying, "I don't think I can help you." No referral, nothing.

Cipro and levaquin was good for the now colonized pseudomonas until I began having reaction to them. This Thursday I'll go back to the hospital for my 3rd PICC line so I can get a round of IV antibiotics--usually ceftazidime. Nothing is on the horizon that will cure the pseudo but we just knock it back. Once that 2 weeks of IV is completed we will try Cayston inhaled antibiotic. Praying I can tolerate it. Finally had to give up on Tobramycin after 6-7 years of effort.