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Any experiences with Kevzara (sarilumab)?
Polymyalgia Rheumatica (PMR) | Last Active: May 1 3:40pm | Replies (114)Comment receiving replies
There is no simplified way to explain it other than to say the effects of Kevzara will wear off in a few weeks after stopping the injections. Then it depends if PMR stays in remission after the injections are stopped and when Kevzara isn't in your system anymore.
Half-life is only part of it. There is also something known as being at "steady state"
"7.7 Biological Half-Life
The half-life will depend on the administered concentration. At 200 mg every 2 weeks, half-life is up to 10 days in patients with rheumatoid arthritis (RA) at steady state. At 150 mg every 2 weeks, half-life is up to 8 days in patients with RA at steady state. After the last steady state dose of 150 and 200 mg, the time to reach nondetectable concentration is 28 and 43 days, respectively."
https://pubchem.ncbi.nlm.nih.gov/compound/Sarilumab
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@dadcue
Steady state simply means that you are replacing with each dosage you take the same amount you are losing in between dosages. In reality the half-life basic rules are the same regardless of steady state status since half-life is a percent of a starting number and not an absolute amount. In my mind the complicating factors are more the individual variables like age, kidney and liver function, exercise, etc that are what get you to a time range for one half-life and not to a single specific amount of time for everyone. I see half-life as an estimate at best.