I have been wondering the same thing. After 20 years, I don’t want to give up, however the pain seems to arrive earlier and earlier. I am about to “start” fresh again = after removing all pills, doctor prescribed and supplements for three months. There was no difference eliminating drugs from my daily routine , and my cholesterol was elevated without a statin. I truly was hoping the statin was the culprit. So, just started, statin, 1 metformin (although not diabetic) and magnesium oil spray at night, along with a magnesium glycinate supplement. I have just ordered an Alpha Lipoc supplement too. I think I should only add one at a time to determine if any relief from magnesium. I have only deteriorated the last four years, fighting the pain, the mobility issues, and mental depression. I appreciate this forum group and Foundation for Peripheral Neuropathy. I wish we had a support group in SW Florida, as Jacksonville is a 5-6 hour drive. I am going to contact our hospital neurology group and “start” again, and be open to suggestions that I have not tried. The chronic pain is mentally wearing me down… So question is what - should I try 1 supplement at a time? Add Alpha Lipoc now and what dosage should I start with?