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Prostate Cancer | Last Active: Apr 28 9:20pm | Replies (65)
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75 years old. Original PSA of 8.6, rapidly growing with high Gleason scores. Eligard shots, and Orgovyx for 22 months after 28 radiation treatments. “Cancer free” 16 months ago with PSA at 0.02 until January 2026 when it rose to 0.06, then to 2.6 on April 2026. Now I’m back on Lupron and taking Xtandi. Cancer cells were not detectable under April PET scan. Had hoped I had it licked but maybe not. Waiting until mid-May for nest PSA yes and more direction.
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@daellingson
At this point, you’re sort of stuck with ADT and an ARPI.
You might ask your doctor about giving you Orgovyx, It has fewer side effects then Lupron For most people and It’s a pill you take once a day.
Have you had any problems with fatigue from Xtandi? Some people can have a lot of side effects from it, But Lupron can also cause fatigue. Not everyone has fatigue, I don’t have any fatigue from the drugs I’ve been taking. I do take Darolutamide Which has fewer side effects than the other lutamides.
How you feel can be a big deal.
If you had Success with getting your PSA undetectable with the two drugs then you really can just keep on them until Your PSA starts rising and metastasis show up In the pet scan. Eventually, the drugs do fail us all.
At that point you have chemo and Pluvicto As options.
It could be years before you even need to consider those, and new drugs are coming out all the time.
Have you had hereditary, genetic testing? At this point, it’s important to do that so you know if genetics has anything to do with your cancer coming back? For some genetic issues, there are drugs you can take.