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Any experiences with Kevzara (sarilumab)?
Polymyalgia Rheumatica (PMR) | Last Active: May 1 3:40pm | Replies (114)Comment receiving replies
@stonewheel
Started Kevzara March 2025 @ abt 8 mg prednisone.
Off all prednisone by 7/15/2025
11/5/2025 chged Kevzara to every 3 weeks because of low WBC.
Jan 2026, blood work normal, stayed at Kevzara 3 week intervals.
Last Kevzara shot 2/22/2026…….stopped cold and no side effects.
Note: I was not, and am not, on any other medications for any other conditions .
I am now 2 months since last shot, blood work shows elevated CRP (10.8). I am not feeling it, 🤞, Dr wants me to restart Kevzara, I’m asking to retest in another 2 months. Wait and see, if a problem reach out to him. Note, I have not heard back yet. 🤞
Replies to "@stonewheel Started Kevzara March 2025 @ abt 8 mg prednisone. Off all prednisone by 7/15/2025 11/5/2025..."
@tweetypie13
I wish I could say I’m not on any other meds! You are truly lucky.
Hope you don’t have to return to the injections. I’m looking ahead and hoping to be injection free.
@tweetypie13 Kevzara has a half life of 10-14 days. That means that only half of a drug is in your system at the end of every half life. Doctors consider 5 half lives to be "completely out of your system" mark. Meaning 50-70 days for Kevzara. You are in this window.
Your CRP being up can be expected to continue going up without drug therapy intervention. I suspect this is why your doctor wants to start you back on Kevzara now and not later.
Ask your doctor about taking injection every 2 or 3 weeks rather than every week and getting 150mg rather than 200mg dose injectable.
Take care and know your doctor is there to keep you out of the ditch and not just help you get out of the ditch.
@tweetypie13
Thank you for sharing. I knew you had stopped Krvzara but wasn’t sure how.
My wish for you is that your pain doesn’t return so you can continue to temain off Kevzara.
@tweetypie13
Thank you for your response. If you haven’t had Kevzara in 2 months 8 weeks) then 6 weeks ago you started your Kevzara taper. If that sounds tight, then it shiukd be out of your system about now (see Mike’s link) at 28-43 days.
I pray your CRP is beginning to go back down. It makes me wonder if adrenal function is messing with your CRP numbers since you are not feeling higher CRP effects. I don’t know.
I am going to continue to follow your progress, as you have been such an inspiration for me.
Keep feeling good girl!
@tweetypie13
Well, I surrender…..I seem to be having “symptoms/senses” of PMR that are not going away. 🙇🏼♀️
I Am taking the Dr’s advice of restarting the Kevzara, as strongly recommended by this group.
My question is to you all, after restarting the Kevzara, how long do we “think” it will take to kick in on my system? It’s been 2 months since my last shot.
(As you know, I don’t understand 1/2 life etc.)
Thx for your thoughts
PS: yes, I have had a smashing “80”th birthday. This next qtr is off to a bang and bring on the fire extinguisher for the candles.
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@tweetypie13 I pray it’s all good.