I think @jeffmarc provides a reasonable perspective. Cribriform does not make surgery “better” than radiation, nor does it make radiation “better” than surgery. Cribriform has its own risk scenario. I did not have it but did have 5 MRI guided radiation treatment in 2023 and would do it again even with Cribriform, as my side effects to this day were low. Many of us, thanks to the helpful folks with real life experiences on this web site, understand the risks and rewards of radiation vs removal. I never saw any high-quality randomized trial for comparisons for those with Cribriform.

I was interested in quality of life and side effects and felt that for me, the risk of side effects with removal, were greater than I was willing to accept. When, and if I encounter BCR, I felt it was more likely, from expert discussions, to be outside of the prostate and as much as catheters do not thrill me, I would accept the cold/heat/electrical BCR solutions currently on the market.