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SHEEESSHHHH - oh well ... : (

Prostate Cancer | Last Active: Apr 28 9:20pm | Replies (65)

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Profile picture for Jeff Marchi @jeffmarc

@melvinw
ASCO also doesn’t recommend ADT with less than .5 PSA.

From Ascopubs about what PSA to do salvage radiation.
≤0.2 ng/mL:
Starting at this level maximizes disease control and long-term survival. Patients treated at PSA < 0.2 ng/mL achieve higher rates of undetectable post-SRT PSA (56-70%) and improved 5-year progression-free survival (62.7-75%).
Delaying SRT beyond PSA ≥0.25 ng/mL increases mortality risk by ~50%.
0.2–0.5 ng/mL:
Still effective, particularly for patients with low-risk features (e.g., Gleason ≤7, slow PSA doubling time). The Journal of Clinical Oncology recommends SRT before PSA exceeds 0.25 ng/mL to preserve curative potential.
0.5–1.0 ng/mL:
Salvage radiation remains beneficial but may require combining with androgen deprivation therapy (ADT) for higher-risk cases.

This article discusses the above;
https://ascopost.com/news/march-2023/psa-level-at-time-of-salvage-radiation-therapy-after-radical-prostatectomy-and-risk-of-all-cause-mortality/

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Replies to "@melvinw ASCO also doesn’t recommend ADT with less than .5 PSA. From Ascopubs about what PSA..."

Thanks so much Jeff 😃, coincidentally I found the same article this very morning and it made me even more determined to push for timely tests and RT planing !

Salvage just have to happen before 0.25 !!! 😠