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@djr5
From what I have read there are no reports of neurotoxicity from mitomycin or Gem/Doce when instilled intravesically into the bladder. Side effects of mitomycin are dysuria, hematuria, UTI, retention, urethral stenosis. Those for Gem/doce are urgency, frequency, bladder spasms, mild flu‑like symptoms. After 8 instillations of Gem/Doce, (3 following the induction period) I have urgency and frequency which have diminished over time, but nothing else. I am not a doctor.

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Replies to "@djr5 From what I have read there are no reports of neurotoxicity from mitomycin or Gem/Doce..."

@gemdoc25 Thank you responding. I have the dubious distinction of being one of a very few who, immediately following intravesical instillation of mitomycin, developed acute toxic metabolic encephalopathy. Specialist Dr. Robert Penn, with the aid of an advanced lab in Utah, determined this over the course of my eight day hospital stay. The medical literature, it seems, reports that mitomycin can be associated with the development of hemolytic uremic syndrome, which in turn can be associated with irreversible renal failure, pulmonary edema, neurologic abnormalities, and has a high mortality rate. I am most grateful to Dr. Penn and my other attending physicians. Dr. Penn charted a 22 page report on the case, which he said may earn me an unwanted asterisk in the medical literature. Dr. Paras Shah, who now treats me at Mayo - Rochester, has reviewed all the copious records of the event. He assures me the drug will be kept far from me.