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Kenalog v. prednisone

Polymyalgia Rheumatica (PMR) | Last Active: Apr 23 7:09am | Replies (10)

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Profile picture for lucasego @lucasego

What you’re describing actually fits pretty well with how Kenalog and Prednisone behave in the body since they’re both corticosteroids acting on the same inflammatory pathways, just with different pharmacokinetics, so it’s not surprising that your deep hip and leg aching from suspected Polymyalgia Rheumatica disappeared after the injection and then gradually returned around 6–8 weeks later as the depot steroid slowly wore off, because triamcinolone injections can provide a fairly long but finite anti-inflammatory effect without the day-to-day dosing flexibility of oral prednisone, and while prednisone is usually the standard treatment mainly because it’s easier to titrate and taper rather than being inherently more effective, there are definitely patients who can’t tolerate it and end up getting partial or temporary control with alternatives like intramuscular steroids, so your response actually supports the idea that your symptoms are steroid-responsive, but it also highlights why rheumatologists tend to prefer oral regimens for long-term management since they can adjust dosing based on sy

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Replies to "What you’re describing actually fits pretty well with how Kenalog and Prednisone behave in the body..."

@lucasego

"prednisone is usually the standard treatment mainly because it’s easier to titrate and taper rather than being inherently more effective"
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True ... tapering off would be more difficult with Kenalog. Secondary adrenal insufficiency might be more of a problem too.
https://pubmed.ncbi.nlm.nih.gov/19197811/