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ARPI use after radiation treatment may be an issue
Prostate Cancer | Last Active: 1 hour ago | Replies (41)Comment receiving replies
@northoftheborder Yeah, but they did not even use PSMA PET scans to draw these conclusions, so perhaps the numbers in reality were much higher.
They stated that they could not detect anything below 10ng/ml, which is a HUGE number.
So basically, they’re saying to scan ‘periodically’ hopefully using PET PSMA and then once they find all these lesions….Chemo??
It’s almost complimentary - yet contradictory - to Dr Wasserug’s theory. He claims early and prolonged ADT does not cause castrate resistance, but that clones bombarded by cosmic rays will bring about this change. However, it seems that these ARSI drugs do just that – give rise to these super clones that do not even produce PSA yet freely metastasize. Thankfully, this phenomenon does not occur in a high percentage of individuals, which probably account for the 230,000 or so prostate deaths each year.
Truly scary all around.
Phil
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@heavyphil That's back to my point that this was a restrospective study, so it was stuck reanalysing data from previous trials which weren't designed with its goals in mind (or may have been designed before newer imaging tech was available).
Retrospective studies are an inexpensive way to spitball new ideas using old research (that's already been paid for), but, as I've mentioned before, at the patient level we probably shouldn't be paying much attention to them, except maybe "that's interesting, lets see if anything emerges in 5 years."