@charlesprestridge

4 years ago at 66 years if age my PSA doubled from 1 to 2. My PCP sent me to a large Urology clinic, DRE normal. I said there is blood (brown spots) in semen. He said not to worry. PSA went up to 2.8 and MRI was ordered, negative, nothing there. I offered to pay for biopsy and there it was Gleason 3/4 and a lesion estimated to be 20 % of the prostate so sometimes low PSA does not equal no PC in a small percentage of us. The Chief Urologist at UC Irvine (a COE) said that about 10% of us get significant cancer at low PSA and/or MRI invisible. The issue is we might get treated late as a result. For me the driving factor was family history of cancer and brown spots in semen.