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ARPI use after radiation treatment may be an issue
Prostate Cancer | Last Active: 45 minutes ago | Replies (21)Comment receiving replies
@jeffmarc So taking a capsule filled with water or gelatin was just as ‘effective’ as the one drug that did NOT cause an increase in radiographic spread…
I just said that 3 times out loud and started laughing…WTF??
Phil
Replies to "@jeffmarc So taking a capsule filled with water or gelatin was just as ‘effective’ as the..."
@heavyphil
I wouldn’t call it just as effective. That it is not.
The placebo will just allow whatever is going to happen happen. I know in my case, it would cause my PSA to rise excessively and quickly, I mean in a matter of a few months.
When it comes to this doesn’t happen to everyone. I suspect those with more severe cases would have their PSA rise significantly.
Guess I will get a CT scan soon!!!
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@heavyphil Unless I misunderstood the retrospective study, that was a percentage of a percentage, not an absolute number.
So the ARPI + ADT was still far more effective than the placebo + ADT for delaying or preventing cancer progression for mCSPC, but the percentage of progression without PSA rise was higher for the (few) cases with the ARPI than it was for the (many) cases with placebo.
Simple example: if 60 out of 100 people on placebo + ADT and 30 out of 100 on ARPI + ADT see cancer progression within the trial period, and that progression happens without a PSA rise for 5 on placebo and 3 on ARPI, then the *percentage* of people with progression on ARPI who didn't see a PSA rise was higher (10% vs 8.3%), even though the absolute number was lower (3 vs 5).
Yep, numbers are weird. 🙂