@surftohealth88 I take it...Jeff takes it( I think Jeff only takes Nubeqa now?)

I started off ( July 11, 2025) with Orgovyx and Erleada ( love those names..;=) but jesus, they fucked me up at first..I stopped everything for about 2 weeks or so...then started back up with Orgovyx and added Nubeqa a month of so later...( early Sept)...my PSA dropped from 71 to .05 ( mid Sept) to < .02 ( late Oct) and after Christmas >.01 and most recent end of March, still < .01...

I think the first 30 days are a bit tough but your body adapts and then not too bad-hot flashes, chills, a bit sore and stiff..and you gotta take 5 pills/day 1 Orgovyx and 4 Nubeqas w/food.

@surftohealth88
The only problem is that Nubeqa Is approved for metastatic, castrate sensitive Prostate cancer. If you are castrate sensitive, but don’t have metastasis than some doctors will not give you a prescription for it.

It looks like a lot more Doctors are opening up to the fact that it’s a better drug, and will prescribe it anyway.

@surftohealth88 I wouldn't take a small retrospective study too seriously, especially in my choice of med. It's an important contribution to overall knowledge, but for deciding on treatment it's not even the bronze standard, much less silver or gold. Repurposing data collected for a different purpose — especially from more than one past trial — is always fraught.

All of the -lutamides (and even Abiraterone) combined with ADT have shown stunning improvement in overall survival compared to ADT alone for mCSPC, and that's based on massive Phase 3 trials that have done their own primary data collection.

In the end, of course, discuss with your partner's oncologist.