I know this is a little negative but based on my own experience you may want to add into your discussions with your doctors as where it might move to next. Proactive approach is new to some of these guys but more are thinking ahead. My research and personal experience indicates the next stop is the pelvic area and or vertebras or continue onto the next lymph nodes. The only way you will know about ADT is to try it. My advice is to avoid Lupron. Once you take that shot you are in for the long ride and if you bad reactions you have no way out. I have only been on Lupron but refuse it now. If I were to I would chose Orgovyx now . I have had 80 radiation treatments over the last 14 years and continue to prefer SBRT over ADT.