@surftohealth88 ADT (Lupron/Eligard/etc.) may cause a brief “spike” in testosterone which can result in what is called "tumor flare” or “testosterone flare.” This is not a good thing to happen since prostate cancer feeds on testosterone. (This may also cause a spike in PSA.)

However, this spike can be prevented by starting with Bicalutimide (Casodex) a short period of time before starting ADT, which blocks testosterone from attaching to prostate cancer cells, which reduces the risk of tumor (testosterone) flare when hormone therapy is started.

Tumor flare does not last long and will go away as the T level continues to drop.

(Firmagon and Orgovyx work via different mechanisms and don’t result in that T spike.)