@surftohealth88 - Thanks, surf. I'm not much of a worrier. The only thing that gets me is the waiting for the next test. Everything is on the discussion list including the estradiol patch, but docs did not want any changes made until CDx and PET results were back. Makes sense since at this point, they don't know what we're dealing with. Standard wisdom says PSA should be undetectable, not climbing and certainly not at the rate it is. Maybe I'll get the cover of one of those medical journals... "ADT/ARSI...Sometimes It Doesn't Work"😁