Your provided history is detailed and excellent. All I can offer when I expressed my anxiety to my urologist about my extraprostatic extension and surgical margins, is that he said that it is routine to have all blood supply removed with the prostate because any cancer cells left behind (surgical margins) need blood, like any other cells or tissue, to survive. The cells can move..."migrate" so to speak...but they may not survive without blood supply. My argument to my physician was that every cell of normal tissue left in my body needs blood supply, and that if the local blood supply for what may be cancerous cells left behind in me is still present for all of the normal, healthy tissue, then either the normal health tissue will seem likely to die, or the cancer cells still in my body, will easily find blood supply from the normal surrounding cells and tissue with their blood supply. He "danced" after that, not giving me a definitive answer, which told me that more than likely, the remaining cancer cells WILL find blood supply before they die from any lack thereof. All it will take is "one" cancer cell finding blood supply, and it can start me on my journey of BCR and phase two of this disease. Just more "watch and wait" with this frustrating disease. I STILL wonder what would have happened if I had never had my RP surgery or anything else. My dad lived to 99 years 10 months "with" prostate cancer (PSA >200 ng/ml). The last five years of his life were lower quality with diapers and perpetual UTI's and hospitalizations, but...he was alive. MY maternal grandfather lived to 96 "with" prostate cancer. He outlived it, having died of Alzheimer's. It's all retrospect now for me...I had the RP surgery and suffer the daily leaks (I regained 98% continence, but still must wear shields in my undershorts), and I haven't had an erection in a year (I am exactly one-year post-op as of mid-April). We just live - or die - with our life choices. I am hoping for at least 15-20 years, but the nature of my cancer type - pT3b with left seminal vesicle invasion (removed with the prostate) - is such that I have a 25-50% probability of recurrence "within" five years post-op. So...one year down, four to go. "Tick, tick, tick, tick, tick, tick...."