I have been on Anastrozole for one year now. The anxiety started shortly after the first month. It has developed into deep depression. I have some very difficult days. I stopped for a few days and noticed a huge shift to feeling more relaxed and experienced some joyful moments. I’m wondering how much worse it can get. I have breast cancer that has spread to the bones in my spine, neck, legs, pelvic area, and shoulder. So, I live with the anxiety and depression because I have to stay on an AI. I do hold onto my faith in God and his goodness. God bless you.