I've been a Trimix user for years, even before I had RALP three years ago. I've never had an issue with using the needle to inject myself, and the miniscule amount of pain is overwhelmed by the success of the compound. I had ED prior to my RP and the Trimix gave me erections like the good old days. My surgery ruined the nerves that allow erections (which seemingly were in bad shape anyway) and I had two choices available: keep going with the Trimix or have a penile implant. I chose Trimix because it leads to blood filling up the penis and I like that feeling. I believe those men that profess to love their implants, but my wife's desires have waned with time, and I couldn't see going that route unless I was planning on having a lot more sex than we do. I freeze syringes with the Trimix in them and even after two years, the meds still work. That makes Trimix economically sound for me.