@synthiame
My rheumatologist favored hydroxychloroquine (Plaquenil) which is supposed to address joint and muscle pain and fatigue. However. Sjogren's can be progressive and damage organs or impede bodily functions. In my case it is destroying nerves, resulting in peripheral and autonomic neuropathy. My neurologist at Mayo talked to the rheumatologist and recommended that he prescribe mycophenolate mofitil (Cellcept) to suppress the immune system and prevent or slow further damage, in lieu of hydroxychloroquine. He agreed to do that. Another option the neurologist said was available in intravenous immunoglobulin (IVIG). I should mention that the prescription for mycophenolate mofitil is "off label" for Sjogren's, meaning that insurance won't cover it. It would cost in excess of $800 per month, but with Good Rx it's $85 for 90 days at CVS.