@dks2500 I’m being treated at another major medical center, UT Southwestern in Dallas. My doctor has two trials underway asking just that question: how to tell if you will respond. One is using high resolution images of tumors, then following patients for a few years to see if A.I. can predict which will respond and which will not. (To the human eye they all look the same.) The other is using fluid obtained during cystoscopies (sorry - “backwash” for lack of a better term) to ask the same question. My doctor says that right now there is no way to predict, so that’s what he and others are working on.