@cndstegle No drug is 100% safe. need to weigh the pros and cons and one's health issues. No cardiac issues, kidney issues, etc. My infusion center has a nurse practitioner who is excellent and available. So far the only issue I had is a raised rash and itchiness helped with cold compresses, lightheadedness ( might be from coffee?), an spasms in my back which were helped with a warm shower and stretching. I learned from my NP that evenity absorbs best when injected in the abdomen.