I have been on ADT for eight years. I live a normal life. I get occasional hot flashes which I know how to manage and I exercise to keep the effects of the ADT from being a problem.

You might ask to have Orgovyx instead of Lupron. It’s a pill you take once a day instead of an injection that lasts for three or six months. When you stop taking your testosterone, comes back a lot quicker. Many people feel it has fewer side effects, Including me.

How long does he want you on Lupron.. When I had my six month shot of lupron two months before my salvage radiation I didn’t even notice any side effects. When I had to go on it full-time about three years later, I had really severe hot flashes right away. There are number of solutions for that. If you have to stay on ADT for a long time, then there are a number of side effects. You need to be aware of.

Due to their different mechanisms of action. ADT which includes Orgovyx, Firmagon, Lupron, Eligard, Prostap, Camcevi, Lucrin, Zoladex, Trelstar, Pamorelin, and Decapeptyl can cause numerous side effects. Actually due to a lack of testosterone.
Hot flashes
Fatigue
Muscle deterioration
Bone weakening
Brain fog
Depression
Weight gain
Joint pain
Difficulty in breathing

Not all of these side effects occur to everyone on the drugs. Most of them are just things you have to be aware of and circumvent. I jog on the track twice a day, 1 mile at least, to help prevent bone weakening, fatigue and muscle deterioration. I also go to the gym three days a week (usually) and spend an hour with all different types of weight exercises. One thing that happens is people get a beer belly from the muscle deterioration, I do a lot of sit-ups to offset that.

Some people get depression but it is not common. It is easily treatable, according to people that have reported it on here and on Online Meetings I have participated in. If he has that problem Come back and ask for help, Or see a psychiatrist about doing something to relieve the depression.

Some people get no hot flashes at all. Others only have a few hot flashes and they are very minor. I had severe hot flashes for the first year on Lupron. As a hot flash was hitting I would feel a lot of fatigue. After a year, my oncologist prescribed a depo-provera shot every three months and it really stopped those hot flashes on Lupron. There are other hormones that can do this, speak to your doctor. If you have this problem, we can give you a list of drugs that can stop it. Ae doctor at a recent conference, put out a big list. I wear an Embrlabs.com Wave 2 device and it works well, reducing the hot flashes and stopping them almost completely at night.
I know one person that says eating tofu every day really controlled his hot flashes, another person in this forum said the same thing. Tofu does have properties similar to endocrine hormones but a lot weaker. Can’t hurt to try it. Seems they ate it daily. Acupuncture works for some people.

According to a doctor that spoke to a recent webinar, many people on ADT, if they are staying on ADT for an extended period or have become castrate resistant should be taking bone straighteners. I took Fosamax for six years and I’m now on Zometa. That along with calcium taken daily helps keep your bones strong. Ask your doctor about this.

I have never gained any weight while on ADT. I get on the scale every morning and base what I eat on what I weigh. Skip lunch at times. Some people gain a lot of weight. The average is 5 pounds but some gain more and some gain none. As it turns out if you are on ADT, you will find it very hard to lose weight. It’s one of the problems with low testosterone. Skipping meals isn’t the answer because your body will burn muscle instead of fat trying to handle the Stress of not enough food.