@tomrennie I was on Gem/Abrax and it caused much more peripheral neuropathy than the Folfirinox I'd had previously. It seems to be very subjective and some people are afflicted and others not. You might talk to your oncologist about cold therapy and the booties/mittens before starting Gem/Abrax. I sure wish I'd have know about the cold therapy before starting on it. "I have a different type of pancreatic cancer." Is it the acinar cell type?