I get up at 5 and take the Linzess with 6-8 glasses of “warm” water. Wait 1/2 hour then eat breakfast. Try to move around and should start to effect you within 1/2 hour to 45 min. I also take MiraLAX at 6:30 pm mixed with Mag citrate powder and this helps. I also started on the vibrant capsule which causes peristalsis in my colon . All this and I go. I have a lot of scar tissue and no movement without this. It’s a total pain in the A but it works! Linzess doesn’t work for me on its own.