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Support For Those Quitting Prolia
Osteoporosis & Bone Health | Last Active: 2 days ago | Replies (272)Comment receiving replies
@rjd I am new to this site but have been reading several replies with you, @windyshores and @formisc. I had my first Prolia shot in June, 2025 with my Endocrinologist, after being on Alendronate for 2 1/2 years prior. I wasn't told about any of the side effects, just that it was an injection every 6 months. I thought, that would be great instead of taking Alendronate every week. A few days after receiving the shot, I started getting pains in my right thigh/hip area and thought it was due to getting ready for a family reunion 5 days later. Well, come the day we left, I couldn't even put weight on my right side, and the pain was getting worst and could barely walk. I was trying to figure out what I had done differently to cause such pain. Then remembered the shot so I pulled it up on phone during travel, and sure enough, thigh pain was the first thing that I saw as a side effect. So, come December, when I was to get my 2nd shot, I told them I didn't want to continue with Prolia, so she put me back on Alendronate. With all this turmoil, I ended up finding a new Endo Dr. and she told me stop taking the Alendronate.
Now, I'm concerned about rebound with not being on anything now. With asking questions on other websites of 2 1/2 yrs on Alendronate, 1 shot of Prolia, back on Alendronate for 1 month and then not taking anything since January 2026, it looks like I'll be okay but I'm still scared. Any insight you have would be appreciated. Thanks in advance!
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@harleysweet64
@harleysweet64
By putting you back on alendronate, your first endo appears to have followed protocol at the time of stopping Prolia after only one injection. What did the second endo tell you when h/she recommended stopping the follow-up alendronate? Were you still having hip pain? What Dexa scores are involved?
McCormick says in Good Bones that the CTX biomarker should be taken when Prolia is stopped and then again every couple of months while on alendronate to monitor whether its use is sufficient to avoid the rebound effect or whether a more powerful bisphosphonate like Reclast should be used.
There is no way to know your response to only one Prolia injection.....by this I mean how rigorously your body reduced osteoclast activity. The general rule per McCormick is that the more rigorously your osteoclasts are suppressed by Prolia, the more likely the rebound will be pronounced when you stop Prolia. Even without a baseline, it might make sense to do a CTX now to address your concern.
Is there something now that makes you question the second endo's recommendation in January to stop alendronate?
In any event, I do hope you have incorporated into your life dietary changes and targeted exercise known to help with osteoporosis.