I had a PIRADS 4 lesion that obviously was the concern. I went into my biopsy and they took several specific bites of the apple and then did the basic template random dozen bites. When I went to see my Urologist afterwards for the info, he told me he had good news and bad news. The good news was the PIRADS 4 lesion was benign ( the purpose of the biopsy) which surprised him, but then the bad news, the random cores identified two Gleason 6, two Gleason 7 (3+4) and one Gleason 8 (4+4). He did explain to me a concerning PIRADS lesion can come out benign. It was fortunate their was a PIRADS 4 that hastened my probably future biopsy later down the line when symptoms may have gotten worse and the cancer left the capsule