@cathyf31 Those are good thoughts. I haven't experienced the difference. At home, I take the pen out of the fridge before bedtime. By the time I did the injection, at least 30-60mins (I was good at stalling! 🙂 ) had gone by, enough to warm up to room temperature. When, I'm in the van, sometimes it was colder than room temperature. I don't recall feeling different effects. That said, I didn't pay enough attention to that thought. I just looked up the package, it mentions 77°. Summer time can be much warmer than that without AC. So, sticking it the fridge daily worked well.