Not sure why but they did some genetic test on me, tested 85 genes. All seemed fine except one and they aren't concerned about it. Don't know if this really means anything. Short version of 9 page report.
Report says:
Your hereditary cancer genetic test results are back. Your results showed one variant of uncertain significance (VUS). You can see your results in your chart, and I’ve attached a copy to this message. You can find more details about your results and next steps below.
Variants of Uncertain Significance Gene
Everyone has small changes in their DNA, called variants. Most of these changes are normal and do not cause cancer or other diseases. Sometimes, a DNA change is called a variant of uncertain significance (VUS). This means that scientists aren’t sure yet if the change is harmful or not. As more people get tested and more research is done, scientists may learn more about the variant. Over time, a VUS can be reclassified. About 90% of VUS results are later found to be benign, meaning they do not increase the risk of cancer.
This result means we currently have no hereditary genetic explanation for your or your family's cancer history.
Results
No pathogenic (cancer-causing) mutations were identified from the genetic testing; however, one or more variants of uncertain significance were identified.
Variant of uncertain significance (VUS): No clinical action should be taken solely based on a VUS, clinical management should be based on personal and family history.
5 labs have reported this variant in Clinvar- 4 labs including Ambry currently classify as a variant of uncertain significance. 1 lab, Invitae, currently classifies this variant as likely benign.
@diverjer The classification system is: pathogenic, likely
pathogenic, variant of uncertain significance (VUS), likely benign, and benign. The first 2 are treated as having a significant biological effect. As you can see VUS is in the middle but with more information they tend to be downgraded rather than upgraded. Likely Pathogenic tends to be upgraded as more evidence comes in to remove the 'likely'.