Oh my, yes....My husband had the tri-modality treatment (chemoradiation with MEI Ivor Lewis esophagectomy) followed by 12 months of nivolumab (Opdivo). He was a prime candidate for nivolumab given he has Lynch syndrome and had colon cancer with resection the year prior to his esophagectomy (a rough few years). He had a number of issues with the immunotherapy including fatigue and GI issues - it was a struggle. He did manage to finish the full course of nivolumab but he came away with immune related sides effects including pneumonitis which required long-term high dose steroids for 2 years. Once he came off the steroids, we saw that he also had joint issues (rheumatoid, most likely due to nivolumab as well) and adrenal insufficiency due to the high dose long term steroids. We finally got him off steroids in December of 2025 and his adrenal insufficiency has abated. The steroids actually helped minimize dumping syndrome so now that he is off...well, you know the story. He has been off nivolumab for almost 2 years now and things have gotten better but it has been slow. There is hope at the end!