I’ll relay my experiences for what may be helpful for your daughter. Im 68 so post menopausal which plays into things. I was diagnosed w Sjogrens Disease SD in 2019. Also test positive for RA but the SD has been the most active. Treated for flares w prednisone blasts and tapers. My autoimmune flares elevated in 2025 and by Sept I was diagnosed with interstitial lung disease ILD related to the SD attacking my lungs. Under Mayo care late 2025 I’m now down a path of seeing if rituximab will slow disease progression. I’m on supplemental oxygen for lungs.
Had two infusions in Dec and have weaned off prednisone for 7 weeks. The pred took my bones into osteoporosis territory but was very effective in controlling flare symptoms. So far both my ILD and inflammatory arthritis seem to be holding steady with rituximab as only therapy. Just had check w my local
rheumatologist w reassuring labs.
I’m back to Mayo in June for full work up re SD-ILD. If it’s working then will have next infusions in June after Mayo visit. I get my infusions at local center under my local rheumatologist care per Mayo pulmonology and rheumatology protocol and they did very thorough job of the pre-infusion prep with IV steroid, Benedryl and Tylenol with slow infusion rate. I tolerated both very well with no reactions.

All the best for your daughter and next steps. So little data to guide so many decisions especially with complex autoimmune. I’ll report back after June Mayo checkup to let you know how effective the rituximab is for my situation.