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Genetic Codes - PTEN loss (exons 6–9) - Any Clear Studies?
Prostate Cancer | Last Active: 23 hours ago | Replies (7)Comment receiving replies
There’s a clinical trial going on now for people that have PTEN. I’m not sure your husband would qualify, but he may even though you have this other genetic problems.
Here are some links to the actual study
https://www.annalsofoncology.org/article/S0923-7534(25)04936-1/fulltext
https://pubmed.ncbi.nlm.nih.gov/41120017/
https://clinicaltrials.gov/study/NCT04493853
This study will assess the efficacy and safety of capivasertib plus abiraterone (+prednisone/prednisolone) plus androgen deprivation therapy (ADT) versus placebo plus abiraterone (+prednisone/prednisolone) plus ADT in participants with mHSPC whose tumours are characterised by PTEN deficiency. The intention of the study is to demonstrate that in participants with mHSPC, the combination of capivasertib plus abiraterone (+prednisone/prednisolone) plus ADT is superior to placebo plus abiraterone (+prednisone/prednisolone) plus ADT in participants with mHSPC characterised by PTEN deficiency with respect to radiographic progression-free survival (rPFS) per 1) Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 for soft tissue and/or Prostate Cancer Working Group (PCWG3) for bone as assessed by the investigator 2) death due to any cause
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@jeffmarc Thank you so much for sharing this study and trial. I've already shared it with my husband. We head to Duke this month and plan to discuss his genetic results and the trial with the oncologist. Right now, my husband is on Orgovyx and Nubeqa, but I'm already worried about cancer resistance. So far, capivasertib is only approved for breast cancer. This is all new to me, but just to clarify, if enrolled in the study, a person with prostate cancer may receive a placebo? This is the scary aspect - not knowing if you will win or lose in the study.