@susanalka . Sorry to hear about your depression and it getting worse on PMR. I was scared to death when in the early days of PMR. The cytokines (IL-6) does not help. It is an evil cytokine that encourages and one might say causes depression. I had, not only pain, but terribly violent and depressing dreams before I got on prednisone. I was morose and quite down about my future. I thought my life was over. Upon starting 15 mg of prednisone, I felt better each hour. By day two I did not have any nightmares and I slept better than I had in years. For me, prednisone was a godsend. It stopped all the depression. I had hope and was elated. I was not wired but actually functioned better mentally than I had been. Strange, but it (pred) calmed me, not wired me. Yes, I eventually got the digits about pred as everyone does, knowing it is also probably destroying you in other ways. I have been off now since March 1st. Took me 9 months to taper off. So far no PMR. Good luck and work with your prescribing doctor on anti depression meds.