@strongone21 Sorry for the delay in responding. Granisetron 1 mg helps well with nausea. And over time we’re able to coordinate with the doctor to take the tablets in the evening, and this has almost completely relieved the nausea symptoms. Diarrhea went away about two weeks after the start of the first cycle.
Another suggestion might be to try acupuncture to help with persistent fatigue and low energy while on the trial. Based on his oncologist’s recommendation, due to progressive neuropathy (after chemotherapy, not related to the RMC-6236 trial, and medications didn’t help), he started acupuncture and the effect has been very positive: reduced numbness in the fingers and soles, and much more energy throughout the day.