I've been on prednisone since February 25. My rheumatologist started me on 15mg prednisone after getting the first results from my blood work. Three weeks later I was diagnosed with PMR and because 15mg was only taking the edge off the pain, I was bumped up to 25mg. For two days I felt great but then the ache in my shoulders returned but at a much lower level and I had pain in my left hip and right knee. After about two weeks I started feeling full relief again but I still woke up with shoulder and hip pain until my prednisone kicked in. My shoulders would ache by the end of the day after doing light chores around the house. It's still difficult to do even the simplest things in the evening because of my shoulders feeling achy and weak. Last week I started getting horrible acid reflux after everything I ate and was taking Tums all day. My rheumatologist was on vacation so I started splitting my prednisone to 20mg in the morning and 5mg in the evening. That worked. Yesterday, my rheumatologist cut me down to 20mg. So far I don't feel any difference. Maybe splitting my dose helped. I'm going to do the same thing later this week by doing 15mg in the morning and 5mg in the evening. I see my rheumatologist again next week. I don't feel like I've ever been totally pain free for more than a couple of days on prednisone. My shoulders always have an ache to them, but I'm starting to feel more side effects of prednisone so I'm willing to put up with a little pain and discomfort, although I feel severely limited in what I'm able to do because of my shoulders.