Pluvicto Prognosis

Some people have some major side effects from Pluvicto, most don’t. I have heard at least 5 people talk about their experience, In some cases they had to have more time between doses because of the side effects.

I saw a webinar where they discussed a person who lit up the Pet scan With metastasis from head to Legs. He had one Pluvicto Treatment and it almost cleared his pet scan, But his side effects were so bad that he could not take any more treatments

Be aware that it works really well for 33% of people OK for 33% of people and not at all for 33% of people.
If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto To find out if you’ve got Genetic changes Due to the cancer.

If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant.

One person I know Peter who runs the advanced prostate cancer reluctant brotherhood forum has had prostate cancer for 12 years. He’s had every treatment. He had the last one possible, Pluvicto, About six months ago. After three treatments, his PSA went down around .05. It has stayed close to that since. For some people, it works really well for other people. It doesn’t work as well. You just have to try it and see how well it works for your husband.

Here’s some feedback from people at Mayo
https://connect.mayoclinic.org/comment/1380711/
https://connect.mayoclinic.org/discussion/can-anyone-share-their-experience-with-pluvicto/

The thing about a median overall survival stat by itself is that it doesn't tell you how long the tail is on the far side.

So we know that in the phase 3 VISION trial, half of the study group (who took Pluvicto) had passed away ~15 months later than than half the people in the control group (who had whatever the default baseline treatment was).

What about the other half, the ones who responded well to Pluvicto and made it to the far side of the median?

Some of them responded exceptionally well. Did they live another year? Two years? Five years? Are they still alive now?

That's a good point. Pluvicto is still a new treatment relatively. I guess noone really knows and everyone is different.

When approved several years ago Pluvicto was said to help some 30% of men. But I think the trials were done on guys who were pretty far along with their cancer. Now they are using it for guys earlier on so the statistics might be better. I did two Pluvicto infusions last year for my 6th recurrence in the past 11-years. I have gone the circuit: surgery, radiation, chemo, immunotherapy, :Parp inhibitors. In my case Pluvicto was "the best". After only two rounds my PSA plummeted to undetectable and has remained so for 9 months so far. Plus, very low side effect profile. I wish it had been around for me years ago before I started this race. Good luck,

Remember that during the clinical trials for Lutetium-177 (Pluvicto), those patients had exhausted all other options. For many of them, 15 months was an eternity.

The side-effects with Pluvicto are related to the fact that the it affects everything that expresses PSMA - especially tears and saliva, since the lacrimal and parotid glands express the highest amounts of PSMA (without being cancerous).

> has your husband tried chemo already?

@yougnu
What bothers me is that the number show A 50% or greater decline in PSA levels with 60% of the patients. These are more recent numbers.

The thing is, they’ve always gone by 1/3 get really good results 1/3 get OK results. I would consider a 50% decline just an OK result. One guy I know had to decline to almost nothing after three sessions. How does that compare to somebody who only has a 50% decline?

Pluvicto (177Lu-PSMA-617) shows high success rates in treating PSMA-positive metastatic castration-resistant prostate cancer (mCRPC), with over 60% of patients experiencing a 50% or greater decline in PSA levels (a key success metric). Recent studies indicate it can reduce the risk of cancer progression or death by up to 59% compared to alternative hormone therapies.

I can’t find any numbers that show a really good percentage of people getting really great results.