Last treatment just 3 weeks ago… . 24 hr IV through PICC line for 21 days..so continuous flow. . I had to go to Inf Disease Center every day to have the bandage and around the PICC line cleaned and flushed with saline and heparin and then a a new med bag put in and programmed to the machine to dispense 24 hrs daily! This all fit into a fanny pack like bag to be mobil and able to carry around with me …..and sleep with it. So I was on continuous flow 24 hrs a day for 21 days. Last year I was on it only for 14 days so I definitely think the 21 days did the trick as the culture came back “no growth “
I did not personally have any sleep issues with the Zosyn.
All the best to you and your treatments !