Some people have some major side effects from Pluvicto, most don’t. I have heard at least 5 people talk about their experience, In some cases they had to have more time between doses because of the side effects.

I saw a webinar where they discussed a person who lit up the Pet scan With metastasis from head to Legs. He had one Pluvicto Treatment and it almost cleared his pet scan, But his side effects were so bad that he could not take any more treatments

Be aware that it works really well for 33% of people OK for 33% of people and not at all for 33% of people.
If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto To find out if you’ve got Genetic changes Due to the cancer.

If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant.

One person I know Peter who runs the advanced prostate cancer reluctant brotherhood forum has had prostate cancer for 12 years. He’s had every treatment. He had the last one possible, Pluvicto, About six months ago. After three treatments, his PSA went down around .05. It has stayed close to that since. For some people, it works really well for other people. It doesn’t work as well. You just have to try it and see how well it works for your husband.

Here’s some feedback from people at Mayo
https://connect.mayoclinic.org/comment/1380711/
https://connect.mayoclinic.org/discussion/can-anyone-share-their-experience-with-pluvicto/

The thing about a median overall survival stat by itself is that it doesn't tell you how long the tail is on the far side.

So we know that in the phase 3 VISION trial, half of the study group (who took Pluvicto) had passed away ~15 months later than than half the people in the control group (who had whatever the default baseline treatment was).

What about the other half, the ones who responded well to Pluvicto and made it to the far side of the median?

Some of them responded exceptionally well. Did they live another year? Two years? Five years? Are they still alive now?

That's a good point. Pluvicto is still a new treatment relatively. I guess noone really knows and everyone is different.

When approved several years ago Pluvicto was said to help some 30% of men. But I think the trials were done on guys who were pretty far along with their cancer. Now they are using it for guys earlier on so the statistics might be better. I did two Pluvicto infusions last year for my 6th recurrence in the past 11-years. I have gone the circuit: surgery, radiation, chemo, immunotherapy, :Parp inhibitors. In my case Pluvicto was "the best". After only two rounds my PSA plummeted to undetectable and has remained so for 9 months so far. Plus, very low side effect profile. I wish it had been around for me years ago before I started this race. Good luck,

Remember that during the clinical trials for Lutetium-177 (Pluvicto), those patients had exhausted all other options. For many of them, 15 months was an eternity.

The side-effects with Pluvicto are related to the fact that the it affects everything that expresses PSMA - especially tears and saliva, since the lacrimal and parotid glands express the highest amounts of PSMA (without being cancerous).

> has your husband tried chemo already?

Thanks everyone

Interesting reading, as usual...CAl77 had it best...it's new, so there's not a lot of empirical data.

I'm starting after PET-PSMA showed activity in the bone and the prostate after being quiet (no abnormal hypermetabolic activity) for 2 years...T is still low (18). My Doctor and I chose Pluvicto rather than Xofigo because of the metastasis to soft tissue as well as the bone (L4).

I'm starting next Tuesday and await the treatment. I, too, have been through all the series of different treatments and, although the new SUV was relatively low, I can't take any chances...It's, as I've said before, a 'crap-shoot'..."darned if you do, darned if you don't".

I also have the questions about the info from the manufacturer..."15.3 months vs. 11 months"...What the hell is that supposed to mean??? If I had 11 months to live and my Doc didn't tell me that, I'd be pissed!!!

I have to read that in terms of extending my lifespan...NOT in terms of months, but by percentages...

I'll keep y'all posted as to the results...Oh, it's not going to be the PSA solely, rather the scan after ...3-4 treatments...

Blessings to all

Howdy North of...

Oh, I'm aware of that, thanks...but I find it interestingly scary to advertise that for people that don't have statistical education or training...LOL...no offense to anyone...but I can see how it would freak someone out!!!

I really DO thank you for the support...I meant that my 5 years of treatment has been a series of either no information or ...hmmm...BS...'sorry!...

I prefer to stay on top of things the best I can, read statistics but not necessarily believe them without finding myself in denial...Everybody is different in so many ways...physically, emotionally, psychologically...

Best regards

Yes, from a physics PoV, I think, "X-ray" just means any type of photon radiation: it was discovered first, and the "X" was because they initially didn't know what it was. By the time they got to other varieties, like ion or proton radiation, they knew what they were looking at (hence, no "Y-rays" or "Z-rays" 🙂, though they do have alpha, beta, and gamma).

In a medical context, as @jeffmarc mentions, the old term "X-ray" has stuck around just for imaging; for therapeutic uses, they use more specific (and modern) terminology.

Disclaimer: I'm a language nerd, not a science nerd, so I may have gotten some technical details wrong.

Howdy,
I'm starting Pluvicto this coming Tuesday. I have to travel 60 miles for my treatment.
I had concerns also about the radioactivity and being in contact with others. The nurse told me contamination is more-so from bodily fluids: sweat, anything expelled from the mouth by sneezing even breathing, urine (of course), feces.
I've engaged medical transportation and was told to wear a surgical mask, clothing that covers the entire body and and nitrile gloves for that hour travel, and that would be okay.
I've already done all my shopping and will not be in contact with anyone for the prescribed time period after getting home.

Blessings for success!!