@pkappy After being accepted for a clinical trial at the NIH in MD due to my original DNA test showed I had the BRCA 2 mutation and acinar cell cancer, they put me on Olaparib (Lynparza) for 3 months and it was not effective. So, I was released from the trial. Back home, I went to the local VA med. ctr. and their oncology dept. for treatment. The onc. doc there was very good and couldn't understand why the Olaparib had not been effective, as with my BRCA 2 mutation and acinar cell cancer, it should have been. He ordered another DNA test of tissue from a biopsy and it showed I'd had a reverse BRCA 2 mutation. Told me it was very rare, but happens. Put me on Gemcitibine/Abraxane and it did some good. I'm on a chemo break now, and the cancer has started to metastasize again. But I can see why Lynparza is working for you it's good to know it is actually effective with the BRCA 2 mutation. Thank you for your time and post.