Choosing between Fosomax and Prolia

About five years ago, I had a bone density exam! It indicated I had osteoporosis in my back and hips! I am a former marathon runner, so big surprise for me! After, talking to my doctor, I decided to go with Prolia! I get shots every six months with very few side effects! Weak stomach, so Fosomax was not a good option for me!

I am on the brink of deciding whether to go with Prolia with 6 month injections. Since I am a very sensitive, intolerant / Almost allergic person to so many things like gluten, corn, wheat, and sesame seeds, I am very concerned about getting this routine. Also, I don’t need dental work now, but I consulted my dentist / surgeon Who suggested I go on Prolia Since it doesn’t remain in the system that long. I would like to hear from people who have had side effects from these injections. Also, I would like to know what holiday or end / Termination of Prolia Have you planned? I was told that you need to set up a termination before you start with your doctor. Thank you for your helpful comments.

@aunt2jack I’m glad you’re seeing an endocrinologist. That makes sense about you not going on Evenity if you have heart disease.

I’ve gained five pounds on Evenity. I’m glad it wasn’t more even though those five pounds are annoying. I hope they’ll come off once I stop.

I am concerned about the rebound effect if you come off Prolia. Prolia doesn’t suppress the formation of osteoclasts like a bisphosphonate does. The osteoclasts continue to develop but are held in an immature stage of development. Once Prolia is stopped, they rapidly mature and go to work destroying bone. So, you end up with a flood of newly mature osteoclasts all at once.

A bisphosphonate taken after Prolia can help slow down this rebound effect but bottom line is that you have a bunch of new osteoclasts going into action all at once.

What happens if you can’t take a bisphosphonate? Say you develop osteonecrosis of the jaw? Or you have a serious side effect?

All of this is just too much risk for me. A lot can happen in a decade or two. Perhaps if I reach my 80s it might be an option I’d try. But at 64, no way.

That said, people do take Prolia without issue for many years.

I am on the brink of deciding whether to go with Prolia with 6 month injections. Since I am a very sensitive, intolerant / Almost allergic person to so many things like gluten, corn, wheat, and sesame seeds, I am very concerned about getting this routine. Also, I don’t need dental work now, but I consulted my dentist / surgeon Who suggested I go on Prolia Since it doesn’t remain in the system that long. I would like to hear from people who have had side effects from these injections. Also, I would like to know what holiday or end / Termination of Prolia Have you planned? I was told that you need to set up a termination before you start with your doctor. Thank you for your helpful comments.

I am on the brink of deciding whether to go with Prolia with 6 month injections. Since I am a very sensitive, intolerant / Almost allergic person to so many things like gluten, corn, wheat, and sesame seeds, I am very concerned about getting this routine. Also, I don’t need dental work now, but I consulted my dentist / surgeon Who suggested I go on Prolia Since it doesn’t remain in the system that long. I would like to hear from people who have had side effects from these injections. Also, I would like to know what holiday or end / Termination of Prolia Have you planned? I was told that you need to set up a termination before you start with your doctor. Thank you for your helpful comments.

I’m waiting to start Fosomax until I talk to my physician. I’m 5’1” and I want to know if I should be taking the same dose as taller, more heavily boned patients.
Also, readers do you actually stand for 1/2 hr after taking the pill?

@alto22

Have you and your doctor/endocrinologist?
discussed drug sequencing? I am not a physician and I don't know your medical history but it seems to be new knowledge that starting sequencing of osteoporosis drugs with a bisphosphonate can diminish the bone building effectiveness of an anabolic drug. If you haven't already, spend time looking through the history of posts under the heading of Osteoporosis. That and doing whatever other research you can help in making your decisions.