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Profile picture for Jeff Marchi @jeffmarc

Really sounds like you made a good decision moving your treatment. Sorry to see your PSA is rising so quickly. Hopefully the radiation will make a big difference and with Lupron you’re not going to notice any PSA rise for a while.

Is there some reason you didn’t try to get Orgovyx Instead of Lupron? It does seem to have slightly fewer side effects for some people. How long did they say you would be on Lupron? Orgovyx Is a pill you just take once a day.

You should talk to your doctor about putting you on an ARPI. The Problem is that staying on ADT alone can cause you to become castrate resistant too soon. If you are on an ARPI like Darolutamide or apalutamide They can delay the amount of time it takes to become castrate resistant. This is actually Done more frequently now that doctors have become aware of the problem with castrate resistance. Speak to the oncologist at Duke about this. They may talk to you about putting you on Zytiga instead. That drug has a lot more side effects and there’s really no solid reason you should do that drug first. Darolutamide does have the least side effects of the lutamide drugs.

Just some things to think about and discuss with your doctors.

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Replies to "Really sounds like you made a good decision moving your treatment. Sorry to see your PSA..."

@jeffmarc
I appreciate your comments and suggestions very much, I'll add them to my notes for next round of questions.
The length of time for ADT will be 6 months.
I did specifically bring up taking Orgovyx, the decision had nothing to do with insurance/cost, and my oncologist took the time to clearly explain the options. I came to feel that Lupron for my situation at this point in time was the better choice, specifically due to the extended tapering off after 6 months should overlay well with the extended effect of radiation once that ends.
I feel that unless there is very good reason Lupron will be a one-time use, with Orgovyx or its replacement will be waiting for future use if needed. I'm otherwise in good health, exercise, and fingers/toes crossed for few side effects.
Thanks again, I appreciate your comments.