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← Return to Kevzara or Methotrexate
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I'm in the same boat. Diagnosed october 2025, started on 15mg, went up to 25mg. Tapering 1mg every 7-10 days. I was doing well, but went to 14mg the other day and I'm having pain, can't walk my 2.5 miles now without it feeling like I have 20 pound weights on my legs and someone is pushing me back with every step forward. I was going to ask about kevzara, but I read you should be under 10mg before starting that. I'll be following you to see how it goes! Good luck to you.
Replies to "I'm in the same boat. Diagnosed october 2025, started on 15mg, went up to 25mg. Tapering..."
@mech
When I went on Kevzara l nothing was said abt prednisone levels. It was all based upon that I could not taper off prednisone without help.
Check with your doctor .
Also prednisone taper might be too fast. My Dr had me ……
Never taper more than 10%, stay at dose until pain free…..tapering while in pain is not helpful to me. You can try the alternating method…..
I.e., 25 going to 24…..alternate days of 25 and 24 until pain free minimum of 2 weeks. That equals a dose of 24.5……then repeat then alternate again try and repeat. Some drops are too big.
@mech on the Kevzara website, scroll down to see the taper chart/graph. Their study group patients were taking 15 mgs/day when they began taking Kevzara.
https://www.kevzara.com/hcp/pmr/efficacy/study-design
I started Kevzara while taking Prednisone 25mg/day (12.5mg am + 12.5 mg pm)
I tapered to 20mg/day (10+10) later that week.
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@mech
There is no requirement to be under 10 mg of Prednisone before starting Kevzara. I think 10 mg is roughly the dose that people often begin to experience more difficulty with tapering their Prednisone dose lower. It is hard to say why this happens. It could be withdrawal symptoms or increased activity of PMR symptoms. No two people are the same. I don't think having difficulty at 14 mg would be too unusual. Tapering by 1 mg every 7-10 days might be too fast though.