@gerryp Assume your urologist and the folks at Mayo Jax are fully aware of your medical history, getting off the baby aspirin may be all you need to prepare. I've had 2 transpireneal biopsies in the last couple years with no issues. Local anesthesia (lidocaine), fully awake and chatting with urologist during, minimal discomfort during, took 10-15 minutes both times. Drove myself to both procedures. Good luck!