I chose Reclast for a few reasons: Highly studied, has been around for 19 years; yearly infusion rather than q6m; my mother took it (although I don't know if it helped her or how many infusions she had; a friend took it with no issues); lots of information about protocols to use to reduce likelihood of flu like symptoms (long infusion time (45 min to 1 hour rather than standard 15 min), saline infusion with it for hydration, Tylenol regularly day of and 2 days after, covered by Medicare B and my supplement. I also had Evenity with good results. I had my first Reclast about 3 weeks ago and did not have side effects (so far).