@denis76
Actually, low testosterone Levels alone don’t lead to resistance. I’ve quoted Richard Wassersug In a couple of messages in this forum. He’s been on estradiol for 22 years and it has kept his testosterone undetectable for all that time. He has not become castrate resistant. So low testosterone alone won’t lead to resistance.

They found that any of the ARPI’s can delay that resistance from coming on, So ADT alone may be a culprit in some respects. I was on ADT alone for 2 1/2 years and became castrate resistant, That was before they realized adding an ARPI with delay it.

Sure, people survived Before lutamides And Zytiga. My father died in 2008 at 88 years old. He had prostate cancer for years, but I remember the day he told me Lupron stopped working. He was a little panicked. He died within a year or so of prostate cancer. When I was a teenager, he had his teeth ground down and crowned without Novacaine, he had so much pain resistance. He would come home and eat dinner with us after that. The last few weeks before he died of prostate cancer he was in so much pain that he needed so much morphine that he couldn’t really communicate. Yes, people survived without ARPI drugs, but many of them died painfully.