I'll be eliminating the 5 mg of tadalafil I've been taking for a while to see what happens. !
Thanks so much for reporting your experience!
I've been experiencing very similar things. I.e. pain in one of my thighs, hip, shoulder. The thigh and hip pain at times can keep me from sleeping. The pains are intermittent and variable. Some times on some days I experience no pain at all.
My first thought was my exercise program. Once I heard that exercise oncologists have discovered that increased muscle mass is directly related to better prostate cancer outcomes for those on ADT, I've never been so religious about aiming to increase my muscle size, almost regardless of pain. Nevertheless, I've had to stop doing certain exercises involving the thighs because the pain was severe enough I thought I must be doing damage. I added stretching and strengthening exercises of the type recommended by physical therapists for hip pain to my daily routine, but some days I wonder if these are making things worse.... I also added periodic rest days. These seem to help. The thing is, I am used to being suddenly subject to dramatic increases in what my body is expected to do and I am familiar with how it feels to experience the pain of muscle overuse and how it feels to recover and come back stronger. These pains I've been experiencing lately are not responding like that.
Another idea I had is that my symptoms were a possible side effect of Orgovyx. Apparently as many as 30% of patients on Orgovyx can experience some sort of "musculoskeletal" pain, This is defined as "myalgia (muscle pain), arthralgia (joint pain), back pain, pain in extremity, bone pain, and musculoskeletal stiffness". Data supporting this also comes from a recent study of the FDA database of adverse events reported since Orgovyx has been in widespread use. https://pmc.ncbi.nlm.nih.gov/articles/PMC11495556/.
However, my medical oncologist asserts that whatever I'm experiencing has nothing to do with his prescription for Orgovyx. I'm not sure why he is so certain. So far I'm not going to experiment with cutting out the Orgovyx for any length of time. I am grateful it is having its intended effect on the cancer.
@climateguy I applaud you whole heartily for your tenacity! Working out under this sort of muscle ache is not for for the faint of heart.
I do a morning high-intensity workout (Scientific Seven Minute Workout) everyday. But yesterday, my thighs, shoulders and glutes starting seizing up during the exercises that hit the core hardest so bad that I had to stop (planks/pushup rotations/side planks) . Today, I didn't take my Cialis yesterday and was able to do my workout this morning (though I feel a bit of the residual ache).
I did find this study (because you know that's all we do, hunt down studies) https://pubmed.ncbi.nlm.nih.gov/16034469/
that indicated that the myalgia (muscle ache) does not cause actual harm. "In a prospective study in healthy volunteers, no substantial changes were observed in laboratory markers indicative of inflammation or muscle damage, and tadalafil did not affect renal plasma flow nor produce lumbar or gluteal myositis by positron emission tomography scan or magnetic resonance imaging. "
So, according to them, the pain doesn't indicate harm. Hopefully, that's the case.
Hang in there climateguy-you're in my thoughts!