Last March my eye doctor started me on AREDS 2, which had more than 2,000x my RDA of copper and high zinc (switched to Macuhealth); my multivitamin addes another 1,000x. I started having colitis flares but assumed that was just my wonky inflammed body. My kidney function before was stage 3a, and by July was 3b, and my MGUS turned into smouldering multiple myeloma (SMM). Eight months later, I stopped the AREDS and the multivitamin and switched to B complex. I don't know if the very high levels of copper and zinc influenced the inflammation, CKD, and/or SMM, but that is a problem when we have complex health issues, is there cause and effect, or just chance.